Radiation-inducible immediate-early gene IEX-1; immediate early protein GLY96; immediate early response 3 protein; PACAP-responsive gene 1 protein; protein PRG1; differentiation-dependent gene 2 protein; protein DIF-2 (IER3, DIF2, IEX1, PRG1)

Function

• may play a role in the ERK signaling pathway by inhibiting dephosphorylation of ERK by phosphatase PP2A-PPP2R5C holoenzyme
• interacts with the PPP2R5C-PP2A holoenzyme & ERK kinases; regulates ERK dephosphorylation

Structure

• glycosylated
• belongs to the IER3 family

Compartment

• membrane; single-pass type 2 membrane protein (putative)

Expression

• induced by radiation, TPA, okadaic acid & TNF-alpha

More general terms

• glycoprotein
• membrane protein

Database

• UniProt: http://www.uniprot.org/uniprot/P46695.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=8870
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:8870
• OMIM: https://mirror.omim.org/entry/602996