phosphatase-2A regulatory subunit B' gamma (PP2A, B subunit, B' gamma isoform; PP2A, B subunit, B56 gamma isoform; PP2A, B subunit, PR61 gamma isoform, PP2; B subunit, R5 gamma isoform; renal carcinoma antigen NY-REN-29; PPP2R5C)

Function

• B regulatory subunit might modulate substrate selectivity & catalytic activity, & also might direct the localization of the catalytic enzyme to a particular subcellular compartment
• at least isoform gamma-3 is phosphorylated on Ser, isoform gamma-1 is not

Structure

• belongs to the phosphatase 2A regulatory subunit B56 family

Compartment

nucleus

Alternative splicing

named isoforms=3

Expression

• highest levels in heart, skeletal muscle & brain
• lower levels in pancreas, kidney, lung & placenta
• very low levels in liver

More general terms

• phosphatase-2A B subunit

Additional terms

• phosphatase-2A (ceramide-activated protein phosphatase)

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:5527
• OMIM: https://mirror.omim.org/entry/601645
• UniProt: http://www.uniprot.org/uniprot/Q13362.html