Loricrin (LOR LRN)

Function

• major keratinocyte cell envelope protein
• substrate of transglutaminases
• some Gln & Lys are cross-linked to other loricrin molecules & to SPRRs proteins
• contains inter- or intramolecular disulfide-bonds (probable)

Compartment

cytoplasm. nucleus, nucleoplasm

Pathology

• defects in LOR are a cause of progressive symmetric erythrokeratodermia
• defects in LOR are the cause of Vohwinkel syndrome with ichthyosis

More general terms

• other protein

Database

• UniProt: http://www.uniprot.org/uniprot/P23490.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=4014
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:4014
• OMIM: https://mirror.omim.org/entry/152445
• OMIM: https://mirror.omim.org/entry/602036
• OMIM: https://mirror.omim.org/entry/604117