anti-glutamate decarboxylase-2 antibody

Introduction

Antibodies against pancreatic islet cells with specificity for glutamate decarboxylase-2.

Etiology

• may occur in patients with diabetes mellitus type 1
• found in high titer in stiff-man syndrome

More general terms

• anti-islet cell antibody (ICA)
• anti-glutamate decarboxylase antibody

Additional terms

• anti-glutamate decarboxylase 65 (GAD65) antibody
• diabetes mellitus type 1 (insulin-dependent, juvenile)
• glutamate decarboxylase 2; glutamate decarboxylase 65 kD isoform (GAD2, GAD65)