non-receptor tyrosine-protein kinase TNK1; CD38 negative kinase 1 (TNK1)

Function

• role in negative regulation of cell growth
• tumor suppressor properties
• negative regulatory role in the Ras-MAPK pathway
• may function in signaling pathways utilized broadly during fetal development & more selectively in adult tissues & in cells of the lymphohematopoietic system
• could specifically be involved in phospholipid signaling
• autophosphorylated on Tyr
• interacts with SH3 domain of PLCG1 via its Pro-rich domain

Structure

• belongs to the protein kinase superfamily, Tyr protein kinase family
• contains 1 protein kinase domain
• contains 1 SH3 domain

Compartment

• cytoplasm, membrane

Alternative splicing

named isoforms=2

Expression

• expressed in umbilical cord blood, bone marrow & adult blood cells
• expressed in several leukemia cell lines
• highly expressed in fetal blood, brain, lung, liver & kidney
• expressed at lower levels in adult prostate, testis, ovary, small intestine & colon
• not expressed in adult lung, liver, kidney or brain

More general terms

• tyrosine kinase (protein tyrosine kinase, PTK)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=8711
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:8711
• OMIM: https://mirror.omim.org/entry/608076
• UniProt: http://www.uniprot.org/uniprot/Q13470.html