dual specificity protein kinase TTK; phosphotyrosine picked threonine-protein kinase; PYT (TTK, MPS1, MPS1L1)

Function

• phosphorylates proteins on Ser, Thr, & Tyr
• probably associated with cell proliferation
• essential for chromosome alignment by enhancing AURKB activity (via CDCA8 phosphorylation) at the centromere, & for the mitotic checkpoint

Inhibition:

• inhibited by the ATP-competitive kinase inhibitor, SP600125

Structure

• belongs to the protein kinase superfamily, Ser/Thr protein kinase family
• contains 1 protein kinase domain

Expression

• present in rapidly proliferating cell lines

More general terms

• serine/threonine kinase
• tyrosine kinase (protein tyrosine kinase, PTK)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=7272
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:7272
• OMIM: https://mirror.omim.org/entry/604092
• UniProt: http://www.uniprot.org/uniprot/P33981.html