AP2-associated protein kinase 1 (adaptor-associated kinase 1, AAK1, KIAA1048)

Function

• phosphorylates AP2M1 subunit of adaptor protein complex 2 (AP-2)
• role in regulating aspects of clathrin-mediated endocytosis
• stimulated by clathrin
• interacts with alpha-adaptin & AP-2
• autophosphorylated

Structure

• belongs to the Ser/Thr protein kinase family
• contains 1 protein kinase domain

Compartment

• peripheral membrane
• active when found in clathrin-coated pits at plasma membrane

More general terms

• serine/threonine kinase

Database

• UniProt: http://www.uniprot.org/uniprot/Q2M2I8.html