serine/threonine protein kinase MRCK gamma; CDC42-binding protein kinase gamma; myotonic dystrophy kinase-related CDC42-binding kinase gamma; myotonic dystrophy protein kinase-like gamma; MRCK gamma; DMPK-like gamma (CDC42BPG)

Function

• downstream effector of CDC42 in cytoskeletal reorganization
• role in actomyosin contractility via regulation of MYPT1 & MLC2
• inactive, closed conformation via interaction of kinase domain & C-terminal coiled-coil region
• activation releases kinase domain & permits dimerization & autophosphorylation
• interacts tightly with GTP-bound but not GDP-bound CDC42

Structure

• homodimer & homotetramer via the coiled coil regions

Expression

• expressed in heart & skeletal muscle

More general terms

• serine/threonine kinase

Database

• UniProt: http://www.uniprot.org/uniprot/Q6DT37.html