serine/threonine protein kinase MRCK alpha; CDC42-binding protein kinase alpha; myotonic dystrophy kinase-related CDC42-binding kinase alpha; myotonic dystrophy protein kinase-like alpha; MRCK alpha; DMPK-like alpha (CDC42BPA)
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Function
- downstream effector of CDC42 in cytoskeletal reorganization
- involved in actomyosin contractility via regulation of MYPT1 & MLC2
- interacts tightly with GTP-bound but not GDP-bound CDC42
Structure
- inactive, closed conformation via interaction of kinase domain & C-terminal coiled-coil region; activation releases kinase domain & permits dimerization & autophosphorylation
Expression
- abundant in heart, brain, skeletal muscle, kidney, & pancreas
- little or no expression in lung & liver