testis-specific serine/threonine protein kinase 4; TSK-4; TSSK-4; testis-specific kinase 4; serine/threonine protein kinase 22E (TSSK4, C14orf20, STK22E, TSSK5)

Function

• may be involved in a signaling pathway during male germ cell development or mature sperm function (putative)
• phosphorylates CREB1 on Ser-133 & stimulates downstream signaling
• activated by phosphorylation on Thr-197, potentially by autophosphorylation (putative)
• autophosphorylated (putative)
• phosphorylated upon DNA damage, probably by ATM or ATR

Cofactor: Mg+2

Structure

• belongs to the protein kinase superfamily, CAMK Ser/Thr protein kinase family
• contains 1 protein kinase domain

Alternative splicing

named isoforms=3

Expression

expressed only in the testis

More general terms

• serine/threonine kinase
• testis-specific protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=283629
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:283629
• OMIM: https://mirror.omim.org/entry/610711
• UniProt: http://www.uniprot.org/uniprot/Q6SA08.html