microtubule-associated serine/threonine protein kinase 1; syntrophin-associated serine/threonine protein kinase (MAST1, KIAA0973)

Function

• appears to link the dystrophin/utrophin network with microtubule filaments via the syntrophins
• phosphorylation of DMD or UTRN may modulate their affinities for associated proteins
• part of a low affinity complex that associates with, but is distinct from, the post-synaptic density
• interacts with SNTB2

Cofactor: Mg+2 (putative)

Structure

• belongs to the protein kinase superfamily, AGC Ser/Thr protein kinase family
• contains 1 AGC-kinase C-terminal domain
• contains 1 PDZ domain (DHR domain)
• contains 1 protein kinase domain

Compartment

• plasma membrane, cytoplasmic side (putative)
• cytoplasm, cytoskeleton
• colocalizes with syntrophins at the plasma membrane (putative)

More general terms

• serine/threonine kinase

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=22983
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:22983
• UniProt: http://www.uniprot.org/uniprot/Q9Y2H9.html