serine/threonine protein kinase haspin; germ cell-specific gene 2 protein; H-haspin; haploid germ cell-specific nuclear protein kinase (GSG2)

Function

• required for normal alignment of chromosomes at metaphase
• phosphorylates histone H3 Thr-3 during mitosis
• autophosphorylated on both Ser & Thr
• phosphorylated during mitosis
• phosphorylated upon DNA damage, probably by ATM or ATR

Cofactor: Mg+2

Structure

• belongs to the protein kinase superfamily, Ser/Thr protein kinase family, Haspin subfamily
• contains 1 protein kinase domain

Compartment

nucleus

Alternative splicing

named isoforms=2

Expression

• strongly expressed in testis
• also present in thymus & bone marrow
• low levels observed in prostate, intestine, lung, spleen & lymph node
• expressed in fetal skin, liver, kidney & small intestine
• expressed in proliferating cell lines
• not expressed in non-proliferating cell lines

More general terms

• serine/threonine kinase
• nuclear protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=83903
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:83903
• OMIM: https://mirror.omim.org/entry/609240
• UniProt: http://www.uniprot.org/uniprot/Q8TF76.html