serine/threonine protein kinase N2; protein kinase C-like 2; protein-kinase C-related kinase 2 (PKN2 PRK2 PRKCL2)

Function

• serine/threonine protein kinase
• preference for highly basic protein substrates (putative)
• activated by lipids, particularly cardiolipin & to a lesser extent by other acidic phospholipids & unsaturated fatty acids
• two specific sites, Thr-816 (activation loop of the kinase domain) & Thr-958 (turn motif), need to be phosphorylated for its full activation (putative)
• autophosphorylated
• activated by limited proteolysis with trypsin

Structure

• the C1 domain does not bind the diacylglycerol (DAG)
• belongs to the protein kinase superfamily, AGC Ser/Thr protein kinase family, PKC subfamily
• contains 1 AGC-kinase C-terminal domain
• contains 1 C2 domain
• contains 1 protein kinase domain
• contains 3 REM (Hr1) repeats

Compartment

cytoplasm (putative)

More general terms

• serine/threonine kinase

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=5586
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:5586
• OMIM: https://mirror.omim.org/entry/602549
• UniProt: http://www.uniprot.org/uniprot/Q16513.html