Fas-activated serine/threonine kinase; FAST kinase (FASTK)

Function

• Fas-mediated apoptosis is characterized by FASTK- dephosphorylation & TIA-1-phosphorylation
• both are activated
• FASTK-mediated TIA-1 activation play a key role in apoptosis
• phosphorylated on serine/threonine
• interacts with TIA-1

Structure

• belongs to the FAST protein kinase family
• contains 1 RAP domain

Expression

• expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney & pancreas

More general terms

• serine/threonine kinase

Additional terms

• CD95; Fas antigen; tumor necrosis factor receptor superfamily member 6; apo-1 antigen; apoptosis-mediating surface antigen FAS; FASLG receptor (FAS, APT1, FAS1, TNFRSF6)
• FAST kinase domain-containing protein (FASTKD)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=10922
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:10922
• OMIM: https://mirror.omim.org/entry/606965
• UniProt: http://www.uniprot.org/uniprot/Q14296.html