nemo-like kinase (NLK, serine/threonine kinase NLK, LAK1 protein)

Function

• differentiation of bone marrow stromal cells
• acts downstream of MAP3K7 & HIPK2
• negatively regulates Wnt1 signaling pathway
  • phosphorylates TCF/LEF factors
  • inhibits interaction of beta-catenin-TCF complex with DNA
• negatively regulates phosphorylation & proteolysis or MYB
• may suppress wide range of transcription factors by phosphorylation of coactivator, CREBBP
• interacts with HIPK2 & MYB
• activated by TAK1 (MAP3K7)
• dually phosphorylated on Thr-291 & Tyr-293, which activates the enzyme (putative)

ATP + a protein <--> ADP + a phosphoprotein

Cofactor: Mg+2 (putative)

Compartment

nuclear, lesser amounts in cytoplasm

More general terms

• serine/threonine kinase

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=51701
• UniProt: http://www.uniprot.org/uniprot/Q9UBE8.html