tyrosine-protein phosphatase, non-receptor type 23; His-domain containing protein tyrosine phosphatase; HD-PTP; protein tyrosine phosphatase TD14; PTP-TD14 (PTPN23, KIAA1471)

Function

• negative regulator of Ras-mediated mitogenic activity
• phosphorylated upon DNA damage, probably by ATM or ATR

Structure

• belongs to the protein-tyrosine phosphatase family non-receptor class subfamily
• contains 1 BRO1 domain
• contains 2 TPR repeats
• contains 1 tyrosine-protein phosphatase domain

Compartment

cytoplasmic vesicles

More general terms

• tyrosine phosphatase (protein tyrosine phosphatate, PTP)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=25930
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:25930
• OMIM: https://mirror.omim.org/entry/606584
• UniProt: http://www.uniprot.org/uniprot/Q9H3S7.html