myotubularin-related protein 4; FYVE domain-containing dual specificity protein phosphatase 2; FYVE-DSP2; zinc finger FYVE domain-containing protein 11 (MTMR4, KIAA0647, ZFYVE11)
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Function
- dephosphorylates proteins phosphorylated on Ser, Thr, & Tyr residues & low molecular weight phosphatase substrate para-nitrophenylphosphate
- phosphorylates phosphatidylinositol 3,4,5-trisphosphate (PIP3)
protein tyrosine phosphate + H2O <--> protein tyrosine + phosphate
Structure
- belongs to the protein-tyrosine phosphatase family non-receptor class myotubularin subfamily
- contains 1 FYVE-type zinc finger contains 1 myotubularin-related domain contains 1 tyrosine-protein phosphatase domain
Compartment
- cytoplasm, membrane, peripheral membrane
- localized to perinuclear region
Expression
- expressed in brain, heart, kidney, spleen, liver, colon, testis, muscle, placenta, thyroid gland, pancreas, ovary, prostate, skin, peripheral blood, & bone marrow
- expressed in fetal brain & fetal liver
More general terms
- myotubularin family protein
- zinc finger protein
- tyrosine phosphatase (protein tyrosine phosphatate, PTP)