1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase eta-2; phosphoinositide phospholipase C-eta-2; phosphoinositide phospholipase C-like 4; PLC-L4; phospholipase C-like protein 4; phospholipase C-eta-2; PLC-eta2 (PLCH2, KIAA0450, PLCL4)
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Function
- phospholipase C
- formation of second messengers diacylglycerol & inositol 1,4,5-trisphosphate (IP3)
- activity very sensitive to Ca+2
- may be important for formation & maintenance of the neuronal network in the postnatal brain
1-phosphatidyl-1D-myo-inositol-4,5-bisphosphate + H2O = 1D-myo-inositol-1,4,5-trisphosphate + diacylglycerol
Structure
- contains 1 C2 domain
- contains 2 EF-hand domains
- contains 1 PH domain
- contains 1 PI-PLC X-box domain
- contains 1 PI-PLC Y-box domain
Compartment
- cytoplasm, cell membrane
- localized predominantly at the plasma membrane (putative)
Alternative splicing
named isoforms=5
Expression
expressed in retina & kidney