folate receptor gamma; FR-gamma; folate receptor 3 (FOLR3)

Function

• binds to folate & reduced folic acid derivatives
• mediates delivery of 5-methyltetrahydrofolate to the interior of cells
• isoform short does not bind folate

Structure

• 8 disulfide bonds are present (probable)
• belongs to the folate receptor family

Compartment

secreted

Alternative splicing

named isoforms=2

Expression

• expressed in spleen, thymus, bone marrow,

Pathology

• expressed in ovarian carcinoma, & uterine carcinoma

Notes

• may be produced at very low levels due to a premature stop odon in the mRNA, leading to nonsense-mediated mRNA decay

More general terms

• folate receptor or folate-binding protein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:2352
• OMIM: https://mirror.omim.org/entry/602469
• UniProt: http://www.uniprot.org/uniprot/P41439.html