neuropilin-2; vascular endothelial cell growth factor 165 receptor 2 (NRP2, VEGF165R2)

Function

• high affinity receptor for semaphorins 3C, 3F, VEGF-165 & VEGF-145 isoforms of VEGF, & the PLGF-2 isoform of PGF
• heterodimer with NRP1 (probable). binds PLXNB1

Structure

• belongs to the neuropilin family
• contains 2 CUB domains
• contains 2 F5/8 type C domains
• contains 1 MAM domain

Compartment

• membrane; single-pass type 1 membrane protein

Alternative splicing

• named isoforms=3; A22, A0, A17

More general terms

• cell surface receptor
• glycoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=8828
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:8828
• OMIM: https://mirror.omim.org/entry/602070
• UniProt: http://www.uniprot.org/uniprot/O60462.html