protein kinase C-nu (protein kinase D3, NPKC-nu, protein kinase EPK2, PRKD3, PRKCN)

Function

• Ca+2-independent, phospholipid-dependent
• serine/threonine kinase
• activated by diacylglycerol

Structure

• belongs to the protein kinase superfamily, CAMK Ser/Thr protein kinase family, PKC subfamily
• contains 1 PH domain
• contains 2 phorbol-ester/DAG-type Zn+2 fingers
• contains 1 protein kinase domain

Alternative splicing

named isoforms=2

Expression

ubiquitous

More general terms

• protein kinase C (PKC)

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:2368
• OMIM: https://mirror.omim.org/entry/607077
• UniProt: http://www.uniprot.org/uniprot/O94806.html