Rho GTPase-activating protein 7; deleted in liver cancer 1 protein; DLC-1; HP protein; Rho-type GTPase-activating protein 7; START domain-containing protein 12; StARD12; StAR-related lipid transfer protein 12 (DLC1, ARHGAP7, KIAA1723, STARD12)

Function

• GTPase-activating protein specific for Rho
• activator of PLCD1 in vivo
• induces morphological changes & detachment through cytoskeletal reorganization

Structure

• contains 1 Rho-GAP domain
• contains 1 SAM (sterile alpha motif) domain
• contains 1 START domain

Compartment

cytoplasm (putative)

Alternative splicing

named isoforms=3

Expression

• highest level of expression in the spleen
• lower expression in prostate, testis, ovary, small intestine & colon
• not expressed in thymus

More general terms

• rho GTPase-activating protein (rho-GAP)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=10395
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:10395
• OMIM: https://mirror.omim.org/entry/604258
• UniProt: http://www.uniprot.org/uniprot/Q96QB1.html