GTPase IMAP family member 4; immunity-associated nucleotide 1 protein; IAN-1; hIAN1; immunity-associated protein 4 (GIMAP4, IAN1, IMAP4, MSTP062)

Function

• intrisinic GTPase activity
• higher affinity for GDP over GTP (12-fold)
  • binding requires Mg+2
• phosphorylated at very low levels in resting splenocytes
• rapidly & transiently phosphorylated in response to splenocyte activation (putative)

Structure

belongs to the IAN GTP-binding protein family

Compartment

cytoplasm, cytosol (putative)

Expression

• expressed in spleen, resting T-cells & B-cells
• expression decreases with activation of B-cells or T-cells
• expressed at lower levels in thymus, ovary, colon, small intestine

More general terms

• GTPase, IMAP family
• guanosine triphosphatase (GTPase)
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=55303
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:55303
• OMIM: https://mirror.omim.org/entry/608087
• UniProt: http://www.uniprot.org/uniprot/Q9NUV9.html