transcription factor HES-2 (hairy & enhancer of split 2, HES2)
Jump to navigation
Jump to search
Function
- transcriptional repressor of genes that require a bHLH protein for their transcription
Structure
- contains 1 basic helix-loop-helix domain (bHLH)
- contains 1 Orange domain
- has a particular type of basic domain (presence of a helix-interrupting proline) that binds to the N-box (CACNAG), rather than the canonical E-box (CANNTG)
- C-terminal WRPW motif is a transcriptional repression domain necessary for the interaction with Groucho, a transcriptional corepressor recruited to specific target DNA by Hairy-related proteins
Compartment
Alternative splicing
named isoforms=2
Expression
expressed in placenta
Pathology
- expressed in pancreatic cancer, colon cancer with RER, cervical cancer, head & neck cancers