T-box transcription factor TBX19; T-box protein 19; T-box factor, pituitary (TBX19, TPIT)

Function

• transcriptional regulator involved in developmental processes
• can activate POMC gene expression & repress the alpha glycoprotein subunit & thyroid-stimulating hormone beta gene promoters

Structure

• contains 1 T-box DNA-binding domain

Compartment

nucleus (putative)

Pathology

• defects in TBX19 are a cause of isolated ACTH deficiency

More general terms

• T-box (TBX) protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=9095
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:9095
• OMIM: https://mirror.omim.org/entry/201400
• OMIM: https://mirror.omim.org/entry/604614
• UniProt: http://www.uniprot.org/uniprot/O60806.html