ETS translocation variant 3; ETS domain transcriptional repressor PE1; PE-1; mitogenic Ets transcriptional suppressor (ETV3, METS, PE1)

Function

• transcriptional repressor
• contributes to growth arrest during terminal macrophage differentiation by repressing target genes involved in Ras-dependent proliferation
• represses MMP1 promoter activity

Structure

• belongs to the ETS family
• contains 1 ETS DNA-binding domain

Compartment

nucleus (putative)

Alternative splicing

named isoforms=2

More general terms

• Ets family protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=2117
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:2117
• OMIM: https://mirror.omim.org/entry/164873
• UniProt: http://www.uniprot.org/uniprot/P41162.html