basic leucine zipper transcriptional factor ATF-like 3 (B-ATF-3, Jun dimerization protein p21SNFT, 21 kD small nuclear factor isolated from T-cells, BATF3, SNFT)

Function

• functions as a negative regulator of AP-1-mediated transcription by heterodimerizing with JUN & binding DNA at 12-O-tetradecanoylphorbol-13-acetate response elements (TRE) (consensus: 5'-TGA[CG]TCA-3')
• represses IL2 & MMP1 promoter activities
• interacts with JUN

Structure

• belongs to the bZIP family
• contains 1 bZIP domain

Compartment

nucleus

More general terms

• basic leucine zipper (bZIP) family protein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:5550
• UniProt: http://www.uniprot.org/uniprot/Q9NR55.html