neuronal PAS domain-containing protein 3 (neuronal PAS3, member of PAS protein 6, basic-helix-loop-helix-PAS protein MOP6, NPAS3, MOP6)

Function

• role in neurogenesis (putative)
• efficient DNA binding requires dimerization with another bHLH protein

Structure

• contains 1 basic helix-loop-helix domain (bHLH)
• contains 1 PAC domain (PAS-associated C-terminal domain
• contains 2 PAS domains (PER-ARNT-SIM domains)

Compartment

nucleus

Alternative splicing

named isoforms=6

Expression

ubiquitously expressed in the adult brain

Pathology

• may control regulatory pathways relevant to schizophrenia & to psychotic
• chromosomal translocation t(9;14)(q34;q13) involving NPAS3 is found in a family with schizophrenia

More general terms

• basic helix loop helix (bHLH) family transcription factor

Database

• UniProt: http://www.uniprot.org/uniprot/Q8IXF0.html