class E basic helix-loop-helix protein 40; bHLHe40; class B basic helix-loop-helix protein 2; bHLHb2; differentially expressed in chondrocytes protein 1; DEC1; enhancer-of-split & hairy-related protein 2; SHARP-2; stimulated by retinoic acid gene 13 protein (BHLHE40, BHLHB2, DEC1, SHARP2, STRA13)

Function

• may function as a transcriptional factor to modulate chondrogenesis in response to the cAMP pathway
• ubiquitinated; which may lead to proteasomal degradation
• able to homodimerize or heterodimerize with TCF3/E47
• interacts with ubiquitin-conjugating enzyme UBE2I/UBC9

Structure

• contains 1 basic helix-loop-helix (bHLH) domain
• contains 1 Orange domain

Compartment

nucleus

Expression

• expressed in cartilage, spleen, intestine, lung, > heart, brain, liver, muscle & stomach

More general terms

• basic helix loop helix (bHLH) family transcription factor

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=8553
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:8553
• OMIM: https://mirror.omim.org/entry/604256
• UniProt: http://www.uniprot.org/uniprot/O14503.html