transcription factor 21; podocyte-expressed 1; epicardin; capsulin; Pod-1 (TCF21, POD1)

Function

• role in epithelial-mesenchymal interactions in kidney & lung morphogenesis that include epithelial differentiation & branching morphogenesis
• may play a role in the specification or differentiation of one or more subsets of epicardial cell types
• efficient DNA binding requires dimerization with another bHLH protein
• forms a heterodimer with TCF3 & binds the E box (5'-CANNTG-3')

Structure

contains 1 basic helix-loop-helix (bHLH) domain

Compartment

nucleus

More general terms

• basic helix loop helix (bHLH) family transcription factor

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:6943
• OMIM: https://mirror.omim.org/entry/603306
• UniProt: http://www.uniprot.org/uniprot/O43680.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=6943