Krueppel-like factor 5; basic transcription element-binding protein 2; BTE-binding protein 2; colon krueppel-like factor; GC-box-binding protein 2; intestinal-enriched krueppel-like factor; transcription factor BTEB2 (KLF5, BTEB2, CKLF, IKLF)

Function

• transcription factor that binds to GC box promoter elements
  • activates the transcription of these genes
• ubiquitinated
• polyubiquitination involves WWP1 & leads to proteasomal degradation
• interacts with WWP1

Structure

• belongs to the krueppel C2H2-type Zn+2-finger protein family
• contains 3 C2H2-type Zn+2 fingers

Compartment

nucleus

Expression

expressed only in testis & placenta

More general terms

• Krueppel-like factor

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=688
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:688
• OMIM: https://mirror.omim.org/entry/602903
• UniProt: http://www.uniprot.org/uniprot/Q13887.html