solute carrier family 39 member 4; Zrt- & Irt-like protein 4; Zn+2 transporter ZIP4 (SLC39A4, ZIP4)

Function

• role in cellular Zn+2 homeostasis as a Zn+2 transporter
• regulated in response to Zn+2 availability

Structure

belongs to the ZIP transporter (TC 2.A.5) family

Compartment

• cell membrane;
• recycling endosome membrane
• colocalizes with TFRC in the recycling endosomes
• cycles between endosomal compartments & the plasma membrane in response to Zn+2 availability

Alternative splicing

named isoforms=2

Expression

• highly expressed in kidney, small intestine, stomach, colon, jejunum & duodenum

Pathology

• defects in SLC39A4 are the cause of acrodermatitis enteropathica Zn+2-deficiency type

More general terms

• solute carrier family 39 (SLC39, SLC39A)
• transmembrane 6e protein
• Zn+2 transporter

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:5563
• OMIM: https://mirror.omim.org/entry/607059
• OMIM: https://mirror.omim.org/entry/201100
• UniProt: http://www.uniprot.org/uniprot/Q6P5W5.html