NEDD8-conjugating enzyme UBE2F (ubiquitin-conjugating enzyme E2 F, NEDD8 protein ligase UBE2F, NEDD8 carrier protein UBE2F, NEDD8-conjugating enzyme 2, UBE2F, NCE2)

Function

• accepts the ubiquitin-like protein NEDD8 from UBE1C-APPBP1 E1 complex & catalyzes its covalent attachment to other proteins
• NEDD8 conjugation, 2nd step

ATP + NEDD8 + protein lysine
              <-->
AMP + diphosphate + protein N-NEDD8yllysine

Structure

belongs to the ubiquitin-conjugating enzyme family

More general terms

• ubiquitin-conjugating protein E2 (ubiquitin carrier protein)

Database

• UniProt: http://www.uniprot.org/uniprot/Q969M7.html