ADP/ATP translocase-2 (adenine nucleotide translocator 2, ANT 2, ADP-ATP carrier protein 2, solute carrier family 25 member 5, fibroblast ADP/ATP carrier protein)

Function

• catalyzes the exchange of ADP & ATP across the mitochondrial inner membrane
• interacts with HIV-1 Vpr

Structure

• homodimer
• contains 3 solcar repeats
• the transmembrane helices are not perpendicular to the plane of the membrane, but cross the membrane at an angle
• odd-numbered transmembrane helices exhibit a sharp kink, due to the presence of a conserved proline residue (putative)

Compartment

mitochondrial inner membrane

More general terms

• ADP/ATP translocase
• solute carrier family 25 (SLC25, SLC25A)

Database

• UniProt: http://www.uniprot.org/uniprot/P05141.html
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:292
• OMIM: https://mirror.omim.org/entry/300150