fatty acid-binding protein-2; fatty acid-binding protein, intestinal; I-FABP; FABPI (FABP2)

Function

• thought to play a role in the intracellular transport of long-chain fatty acids & their acyl-CoA esters
• FABP2 is probably involved in triglyceride-rich lipoprotein synthesis
• binds saturated long-chain fatty acids with high affinity
• binds with lower affinity to unsaturated long-chain fatty acids
• FABP2 may also help maintain energy homeostasis by functioning as a lipid sensor

Structure

• forms a beta-barrel structure that accommodates the hydrophobic ligand in its interior
• belongs to the calycin superfamily, fatty-acid binding protein (FABP) family

Compartment

• cytoplasm

Expression

• expressed in small intestine & at much lower levels in large intestine
• highest expression levels in jejunum
• induced by EGF

More general terms

• fatty acid/retinol binding protein family

Database

• UniProt: http://www.uniprot.org/uniprot/P12104.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=2169
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:2169
• OMIM: https://mirror.omim.org/entry/134640