cellular retinoic acid-binding protein 2; cellular retinoic acid-binding protein II; CRABP-II (CRABP2)

Function

• transports retinoic acid to the nucleus
• regulates access of retinoic acid to nuclear retinoic acid receptors
• interacts with RXR & RARA (putative)
• interacts with importin alpha

Structure

• forms a beta-barrel structure that accommodates hydrophobic ligands in its interior
• belongs to the calycin superfamily, fatty-acid binding protein (FABP) family

Compartment

• cytoplasm, nucleus
• upon ligand binding, a conformation change exposes a nuclear localization motif & the protein is transported into the nucleus

Expression

induced by retinoic acid

More general terms

• fatty acid/retinol binding protein family

Database

• UniProt: http://www.uniprot.org/uniprot/P29373.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=1382
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1382
• OMIM: https://mirror.omim.org/entry/180231