tubulin-specific chaperone D (tubulin-folding cofactor D, tubulin-folding cofactor D, beta-tubulin cofactor D, tfcD, SSD-1, TBCD)

Function

• tubulin-folding protein
• component of tubulin chaperone complex
• role in early step of tubulin folding
• TBCA & TBCD function by capturing & stabilizing tubulin in a quasi-native conformation
• modulates microtubule dynamics by capturing GTP-bound beta-tubulin

Structure

• contains 3 HEAT repeats

Alternative splicing

named isoforms=5

Expression

• ubiquitously expressed
• down-regulated by shear stress

More general terms

• chaperonin; chaperone

Component of

• tubulin chaperone complex

Database

• OMIM: https://mirror.omim.org/entry/604649
• UniProt: http://www.uniprot.org/uniprot/Q9BTW9.html