cyclophilin E (cyclophilin 3, 33kD peptidyl-prolyl cis-trans isomerase, cyclophilin 33, rotamase E, PPIE, CYP33)

Function

• PPIases accelerate the folding of proteins
• catalyzes cis-trans isomerization of proline imidic peptide bonds in oligopeptides
• combines RNA-binding & PPIase activities
• may be involved in muscle- & brain-specific processes
• may be involved in pre-mRNA splicing
• identified in the spliceosome C complex

peptidylproline (omega=180) <--> peptidylproline (omega=0)

Structure

• belongs to the cyclophilin-type PPIase family, PPIase E subfamily
• contains 1 PPIase cyclophilin-type domain contains 1 RRM (RNA recognition motif) domain

Compartment

nucleus

Alternative splicing

named isoforms=2

Expression

• found in all the examined tissues including heart, brain, placenta, lung, liver, skeletal muscle, kidney & pancreas

More general terms

• cyclophilin
• chaperonin; chaperone

Component of

• spliceosome C complex

Database

• OMIM: https://mirror.omim.org/entry/602435
• UniProt: http://www.uniprot.org/uniprot/Q9UNP9.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=10450