cyclophilin A (cyclosporin A-binding protein A, peptidyl-prolyl cis-trans isomerase A, CypA, PPIA)

Function

• PPIases accelerate the folding of proteins
• catalyzes cis-trans isomerization of proline imidic peptide bonds in oligopeptides
• interacts with HIV-1 Capsid protein
• binds cyclosporin A (CsA)
• CsA mediates some of its effects via an inhibitory action on PPIase

peptidylproline (omega=180) <--> peptidylproline (omega=0)

Structure

• belongs to the cyclophilin-type PPIase family, PPIase A subfamily
• contains 1 PPIase cyclophilin-type domain

Compartment

cytoplasm

More general terms

• cyclophilin
• chaperonin; chaperone

Database

• UniProt: http://www.uniprot.org/uniprot/P62937.html
• OMIM: https://mirror.omim.org/entry/123840
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=5478