1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase eta-1 (phospholipase C-eta-1, PLC-eta-1, phospholipase C- like protein 3, PLC-L3, PLCH1, KIAA1069, PLCL3)

Function

• production of the second messenger molecules diacylglycerol (DAG) & inositol 1,4,5-trisphosphate (IP3) is mediated by Ca+2-activated phosphatidylinositol-specific phospholipase C enzymes

1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O <--> 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol

Cofactor: Ca+2

Structure

• contains 1 C2 domain
• contains 2 EF-hand domains
• contains 1 PH domain
• contains 1 PI-PLC X-box domain
• contains 1 PI-PLC Y-box domain

Compartment

cytoplasm. membrane

Alternative splicing

named isoforms=4

Expression

• expressed in brain & to a lower extent in lung
• in brain, it is found in cerebrum, cerebellum & spinal cord

More general terms

• phosphodiesterase
• Ca+2 binding protein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:2300
• UniProt: http://www.uniprot.org/uniprot/Q4KWH8.html