beta-defensin 3; beta-defensin 103; BD-3; DEFB-3; HBD3; hBD-3; defensin, beta 103; defensin-like protein (DEFB103A, BD3, DEFB103, DEFB3, DEFB103B)

Function

• antimicrobial activity against
  • Gram-positive bacteria S.aureus & S.pyogenes
  • Gram-negative bacteria P.aeruginosa & E.coli & the yeast C.albicans
• kills multiresistant S.aureus & vancomycin-resistent E.faecium
• no significant hemolytic activity was observed

Structure

belongs to the beta-defensin family

Compartment

secreted

Expression

• expressed in skin & tonsils > trachea, uterus, kidney, thymus, adenoid, pharynx & tongue > salivary gland, bone marrow, colon, stomach, polyp & larynx
• no expression in small intestine
• induced by bacterial infection & by interferon gamma

Laboratory

• Mass Spectroscopy: MW=5154.59, electrospray

More general terms

• beta defensin
• endogenous antibiotic

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=414325
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=55894
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:414325
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:55894
• OMIM: https://mirror.omim.org/entry/606611
• UniProt: http://www.uniprot.org/uniprot/P81534.html