sarcomeric/mitochondrial creatine kinase (S-mtCK, CKMT2)

Function

• reversibly catalyzes transfer of phosphate between ATP & various phosphogens (e.g. creatine phosphate)
• creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain & spermatozoa
• binds cardiolipin

ATP + creatine = ADP + phosphocreatine

Structure

• octamer composed of four CKMT2 homodimers
• belongs to the ATP:guanido phosphotransferase family

Compartment

• mitochondrial inner membrane; intermembrane side

Expression

• sarcomere-specific
• found only in heart & skeletal muscles

More general terms

• creatine kinase
• mitochondrial membrane protein

Database

• UniProt: http://www.uniprot.org/uniprot/P17540.html
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1160
• OMIM: https://mirror.omim.org/entry/123295
• UniProt: http://www.uniprot.org/uniprot/P17540.html