DNA-directed RNA polymerase III subunit RPC5; RNA polymerase III subunit C5; DNA-directed RNA polymerase III 80 kD polypeptide (POLR3E, KIAA1452)

Function

• specific peripheral component of RNA polymerase 3
• essential for efficient transcription from both the type 2 VAI & type 3 U6 RNA polymerase 3 promoters
• role in sensing & limiting infection by intracellular bacteria & DNA viruses
• acts as nuclear & cytosolic DNA sensor involved in innate immune response
• can sense non-self dsDNA that serves as template for transcription into dsRNA
• the non-self RNA polymerase 3 transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type 1 interferon & NF- Kappa-B through the RIG-I pathway
• interacts with POLR3D/RPC4

Compartment

nucleus

Alternative splicing

named isoforms=3

More general terms

• nuclear protein
• protein subunit
• phosphoprotein

Component of

• RNA polymerase 3

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=55718
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:55718
• UniProt: http://www.uniprot.org/uniprot/Q9NVU0.html