Zn+2 phosphodiesterase ELAC protein 2; elaC homolog protein 2; heredity prostate cancer protein 2; ribonuclease Z 2; Rnase Z 2; tRNA 3 endonuclease 2; tRnase Z 2 (ELAC2, HPC2)

Function

• Zn+2 phosphodiesterase
• some tRNA 3'-processing endonuclease activity
• probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA
  • endonucleolytic cleavage of RNA, removing extra 3' nucleotides from tRNA precursor, generating 3' termini of tRNAs
  • a 3'-hydroxy group is left at the tRNA terminus & a 5'-phosphoryl group is left at the trailer molecule

Cofactor: Zn+2 (probable)

Structure

• homodimer (putative)
• belongs to the Rnase Z family

Compartment

nucleus (probable)

Alternative splicing

named isoforms=3

Expression

• widely expressed
• highly expressed in heart, placenta, liver, skeletal muscle, kidney, pancreas, testis & ovary
• weakly expressed in brain, lung, spleen, thymus, prostate, small intestine, colon & leukocytes

Pathology

• defects in ELAC2 may be a cause of susceptibility to prostate cancer

More general terms

• endoribonuclease
• oligomerizing protein
• nuclear protein
• phosphoprotein

Additional terms

• prostate cancer

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=60528
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:60528
• OMIM: https://mirror.omim.org/entry/176807
• OMIM: https://mirror.omim.org/entry/605367
• UniProt: http://www.uniprot.org/uniprot/Q9BQ52.html