Zn+2 phosphodiesterase ELAC protein 1; deleted in Ma29; elaC homolog protein 1; ribonuclease Z 1; Rnase Z 1; tRNA 3 endonuclease 1; tRnase Z 1 (ELAC1, D29)

Function

• Zn+2 phosphodiesterase
• some tRNA 3'-processing endonuclease activity
• probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA
  • endonucleolytic cleavage of RNA, removing extra 3' nucleotides from tRNA precursor, generating 3' termini of tRNAs
  • a 3'-hydroxy group is left at the tRNA terminus & a 5'-phosphoryl group is left at the trailer molecule

Cofactor: binds 2 Zn+2 (putative)

Structure

• homodimer (putative)
• belongs to the Rnase Z family

Compartment

nucleus (probable)

Expression

• widely expressed
• expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney & pancreas

More general terms

• endoribonuclease
• oligomerizing protein
• nuclear protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=55520
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:55520
• OMIM: https://mirror.omim.org/entry/608079
• UniProt: http://www.uniprot.org/uniprot/Q9H777.html