cGMP-gated cation channel alpha 3 (CNG channel alpha 3, cyclic nucleotide gated channel alpha 3, cone photoreceptor cGMP-gated channel alpha subunit, CNGA3, CNCG3)
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Function
- cation channel
- activated by cyclic GMP
- opening of the cation channel depolarizes photoreceptors in cones
- light-evoked electrical responses in the red-, green- & blue sensitive cones
- heterooligomeric complex with CNGB3
Structure
- belongs to the cyclic nucleotide-gated cation channel (TC 1.A.1.5) family
- contains 1 cyclic nucleotide-binding domain
Compartment
membrane
Expression
prominently expressed in retina
Pathology
- defects in CNGA3 are a cause of achromatopsia 2
More general terms
Additional terms
References
- ↑ UniProt http://www.uniprot.org/uniprot/Q16281.html
- ↑ Mutations of the CNGA3 gene Retina International's Scientific Newsletter http://www.retina-international.com/sci-news/cnga3mut.htm
- ↑ GeneReviews https://www.genecards.org/cgi-bin/carddisp.pl?gene=CNGA3