cGMP-gated cation channel alpha 1; CNG channel alpha 1; CNG1; cyclic nucleotide gated channel alpha 1; cyclic nucleotide gated channel photoreceptor; cyclic-nucleotide-gated cation channel 1; rod photoreceptor cGMP-gated channel alpha subunit (CNGA1, CNCG1)
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Function
- visual signal transduction is mediated by G-protein
- activation by cyclic GMP
- opening of cation channel
- depolarization of rod photoreceptors
- forms heterooligomeric complex with CNG4
Structure
- homotetramer or higher oligomer
- belongs to the cyclic nucleotide-gated cation channel (TC 1.A.1.5) family
- contains 1 cyclic nucleotide-binding domain
Compartment
membrane
Expression
expressed in rod cells in the retina
Pathology
- defects in CNGA1 are a cause of autosomal recessive retinitis pigmentosa
More general terms
Additional terms
References
- ↑ UniProt http://www.uniprot.org/uniprot/P29973.html
- ↑ Mutations of the CNGA1 gene; Retina International's Scientific Newsletter http://www.retina-international.com/sci-news/cnga1mut.htm
- ↑ GeneReviews https://www.genecards.org/cgi-bin/carddisp.pl?gene=CNGA1