voltage-dependent anion-selective channel protein 2; VDAC-2; hVDAC2; outer mitochondrial membrane protein porin 2 (VDAC2)

Function

• forms a channel through the mitochondrial outer membrane that allows diffusion of small hydrophilic molecules
• the channel adopts an open conformation at low or zero membrane potential & a closed conformation at potentials above 30-40 mV
• the open state has a weak anion selectivity whereas the closed state is cation-selective
• interacts with hexokinases (putative)

Structure

• consists mainly of a membrane-spanning beta-barrel formed by 19 beta-strands (putative)
• belongs to the eukaryotic mitochondrial porin family

Compartment

mitochondrial outer membrane

Alternative splicing

named isoforms=3

Expression

expressed in all tissues examined

More general terms

• voltage-dependent anion channel
• phosphoprotein
• mitochondrial membrane protein
• transmembrane 19 protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=7417
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:7417
• OMIM: https://mirror.omim.org/entry/193245
• UniProt: http://www.uniprot.org/uniprot/P45880.html