chloride intracellular channel protein 3 (CLIC3)

Function

• can insert into membranes & form chloride ion channels
• may participate in cellular growth control
• associated with the C-terminal of ERK7

Structure

• members of this family may change from a globular, soluble state to a state where the N-terminal domain is inserted into the membrane & functions as chloride channel
• a conformation change of the N-terminal domain is thought to expose hydrophobic surfaces that trigger membrane insertion
• belongs to the chloride channel CLIC family
• contains 1 GST C-terminal domain
• contains 1 GST N-terminal domain

Compartment

• nucleus, membrane
• single-pass membrane protein
• cytoplasm
• predominantly nuclear
• some protein is found in the cytoplasm
• exists both as soluble cytoplasmic protein & as membrane protein with probably a single transmembrane domain (putative)

Expression

• detected in placenta (at protein level)
• widely expressed
• expression in placenta > lung & heart > skeletal muscle, kidney & pancreas

More general terms

• chloride intracellular channel protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=9022
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:9022
• OMIM: https://mirror.omim.org/entry/606533
• UniProt: http://www.uniprot.org/uniprot/O95833.html