K+ channel subfamily K member 5; acid-sensitive K+ channel protein TASK-2; TWIK-related acid-sensitive K+ channel 2 (KCNK5, TASK2)

Function

• pH-dependent, voltage insensitive, outwardly rectifying K+ channel
• outward rectification is lost at high external K+ concentrations

Structure

• homodimer; disulfide-linked
• belongs to the two pore domain K+ channel (TC 1.A.1.8) family

Compartment

membrane (potential)

Expression

• abundant expression in kidney
• also detected in liver, placenta & small intestine
• in kidney, expression is restricted to the distal tubules & collecting ducts
• not expressed in proximal tubules or glomeruli

Notes

• inhibited by quinine, quinidine & external acidification

More general terms

• K+ channel subfamily K
• glycoprotein
• phosphoprotein
• transmembrane 4 protein

Database

• UniProt: http://www.uniprot.org/uniprot/O95279.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=8645
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:8645
• OMIM: https://mirror.omim.org/entry/603493